General Information

  • ID:  hor000015
  • Uniprot ID:  NA
  • Protein name:  neuropeptide hormone
  • Gene name:  NA
  • Organism:  Helicoverpa zea
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  cells in the corpora cardiaca
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ELTFSSGWGN
  • Length:  10
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  The elevation of trehalose and lipid level
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000015_AF2.pdbhor000015_ESM.pdb

Physical Information

Mass: 125785 Formula: C49H68N12O17
Absent amino acids: ACDHIKMPQRVY Common amino acids: GS
pI: 3.85 Basic residues: 0
Polar residues: 6 Hydrophobic residues: 3
Hydrophobicity: -44 Boman Index: -1071
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: 3408 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  3415690
  • Title:  Isolation and Primary Structure of a Neuropeptide Hormone From Heliothis Zea With Hypertrehalosemic and Adipokinetic Activities